Impact of Honeybee Venom Melittin on Cell Viability of Different Prostate Cancer Lineages

Background . Melittin is a major constituent of honeybee venom and comprises water-soluble surfactant peptide with cytolytic effects potentially applicable in anticancer therapy. We evaluated the impact melittin from Bashkir ( Apis mellifera L.) on cell viability various prostate cancer lineages. Materials methods. MTT assays index estimation were used to evaluate effect proliferation various-grade malignancy (PC) lineages, LNCaP, PC-3 DU145. Results discussion. Lineage DU145 revealed low sensitivity melittin, because relatively high concentration 10 μg/mL had suppressive its proliferation. With cells, 0.1 suppressed significantly 46.15 %, while at dose most cells (4.27 % viability). LNCaP experienced lowest toxicity compared The PC lineages demonstrated levels 0.01–100 μg/mL. Conclusion study reveals significant reduction minimal 0.01 μg/mL, which indicates activity this renders it candidate agent antitumour